Medicinext

Medicinext

@med.next

For those, who wants to be updated on future and upcoming innovation within Medicines and treatment options 🌎
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We always talk about drug efficacy and rarely about side effects. Did you know that the most common side effect of pain killers is headache 😂

2 Days ago
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Titin is the largest protein circulating throughout the human body, and it plays a key role in helping muscles function properly—especially in the heart. Now an international team of researchers has discovered a new mechanism that regulates this protein. The insights could help improve the understanding of the many disease processes that damage the heart. The titin protein is like a “molecular spring” that governs how muscle cells contract in a synchronous manner. There are more than 100 regions within the structure of titin called “immunoglobulin domains,” which work together to establish the protein’s elasticity. The researchers discovered that these domains contain high levels of cysteine, which is an amino acid. When two cysteines join up, they can form a bond that’s part of a biochemical process known as reduction-oxidation, or redox. Some cardiac disorders, including heart attacks, are characterized by sudden, drastic changes in the heart muscle’s redox processes. The most interesting finding was that the cysteine bonds could cause “major changes in the elastic properties of titin. Heart disease is the leading cause of death in both men and women, according to the Centers for Disease Control. About 1 in every 4 deaths in the U.S. is attributed to cardiac disease, and 735,000 Americans suffer a heart attack each year. Heart muscle damaged by a heart attack is impossible to fix, though several research teams around the world are working on potential biotech solutions to that problem.

7 Days ago
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Researchers get first complete look at protein behind sense of touch. Scientists have solved the mystery of the structure of Piezo1, a member of a family of proteins that convert physical stimuli such as touch or blood flow into chemical signals. Piezo1 structure is unique because it appears to be an "all-in-one" protein, meaning it does not need to connect with other proteins or cell structures to do its job transmitting a signal. The next step in this research is to examine the overall architecture of Piezo1 and determine how each piece works. Scientists hope to look at this protein in different conformations besides the closed conformation seen in the current study. This gives us a good opportunity to investigate how force sensation, or transduction really works.

11 Days ago
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Brain Computer Interfaces are allowing previously paralysed patients to control their limbs with neural activity, linked to implants in the brain and electrodes in the limbs. Science fiction come true!

15 Days ago
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Laser-equipped shoes help Parkinson’s patients take the next step. Here’s an unexpected but pleasant little way tech might be able to improve a few lives: laser shoes. Yes, seriously. Shoes equipped with small laser emitters were shown in recent tests to help sufferers of Parkinson’s disease to walk normally. One of the possible symptoms of Parkinson’s is what’s called gait freezing, where a person finds themselves unable to take a step despite willing themselves to walk forward. Being unable to move for the duration of the freeze (anything from a few seconds to over a minute) is inconvenient, but it can also cause a person to lose their balance and topple over. Interestingly, during a freeze, a person may be able to break out of it by concentrating on something near their feet that they can step towards or over, such as a floorboard or a crack in the sidewalk. Of course, such a feature is not always present. So what if you could manifest one on demand? 👏

20 Days ago
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Happy new year from @medicinext. Thanks for all your attention and see you in 2018. Take Care. Cheers 🍾🥂

22 Days ago
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Artificial Intelligence (AI) is the key to unlocking the door to Personalized Medicine. AI enables us to go beyond genetic analysis and include vast amounts of environmental factors to personalize treatment to our life experience. AI-driven genetic tests are making a change for the better. Yet; AI enables us to go even further. To look at more relevant data, outside our body, to personalize a therapy. In essence, we may all be dealt a certain deck of cards – our genes, but our environment can dramatically influence our outcomes. In terms of mental health disorders, it is becoming clear through research, that AI and Big Data, can help us delve deeper into understanding the genetic complexities of our psychiatric disorder. We can now in certain health conditions, such as breast cancer, understand whether someone has a genetic predisposition, an increased likelihood of developing a particular disease based on a person's genetic make up.

23 Days ago
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New research shows targeted drug delivery via nanoparticles could help repair transplant organs. An individual nanoparticle molecule behaves as a complete unit in terms of its property and transportation. Rapidly increasing public awareness for nanotechnology and introduction of new technologies will have many beneficial consequences. Due to its ability to deliver peptides, proteins and genes, it is also used as a DNA carrier in gene therapy. Numerous advantages for nanoparticles in drug delivery system is expected 👏

27 Days ago
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I wish you all merry Christmas and a happy new year. Thanks for 2017 👏🍾🥂

30 Days ago
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In a historic step, an approval of a hereditary form of vision loss, marking the first time a gene therapy for an inherited disorder has been cleared. Approval of the treatment, which delivers a functional copy of a gene to restore visual function, represents a major milestone for the fast-accelerating gene therapy field. The drug is the first directly administered treatment for an inherited disease caused by a genetic mutation. The drug is approved to treat a rare retinal dystrophy caused by mutations in a gene known as RPE65, which leads to impaired or altogether absent function from the protein encoded by that gene. Individuals who have RPE65 mutation-associated retinal dystrophy experience vision loss in childhood or adolescence, progressing to complete blindness in some patients. The drug is designed to deliver a functional copy of the RPE65 gene directly into retinal cells, spurring production of the needed protein and restoring vision. What an achievement 👏👏

34 Days ago
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Researchers are shining a light on the tumor microenvironment to accelerate the next generation of cancer treatments. Scanning Electron Micrograph (SEM) showing immune cells (small sphericals, purple) attacking cancer cells (larger bodies, blue). Cancer cells can mutate in ways that make them undetectable to the immune cells. In other cases, a dysregulation in the body can lead to key signals being shut down so the immune system doesn’t respond as it should.

37 Days ago
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Cancer is the second most common cause of death worldwide. In 2017, 10 million people died of tumors. Research teams are working hard on changing that number. fightingcancer

41 Days ago
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Most guys know the wonder drug: “the blue pill”. But what do you think about the little white pill?

47 Days ago
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If you have a history of blood clots in the legs and/or lungs, and now are experiencing shortness of breath or fatigue, talk to your health care provider about CTEPH. Hypertention (CTEPH) is a condition where there is elevated blood pressure in the pulmonary arteries caused by chronic blood clots. followmefollowersinnovationmed onmednextmedicinextlike4follow

50 Days ago
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Diabetes and Adiposity Cause 1 in 20 Cancers Worldwide. Nearly 6% of cancers, equating to almost 800,000 cases globally, were attributable to type 2 diabetes and overweight/obesity, new data show, with adiposity being responsible for almost twice as many cases as diabetes. The study represents the first to estimate the worldwide cancer burden due to diabetes alone and also to diabetes and high body mass index (BMI) combined. followmefollowerscancerfightca ghtcancerfightthecauseinnovati

53 Days ago
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Often times there is so much focus placed on the patient, but behind every patient there is likely a caregiver who is often overlooked. In honor of National Family Caregivers Month, let’s acknowledge these individuals who care for their loved ones, make sacrifices, and face challenges as a result. Caregiving around the clock is no easy feat – whether it’s juggling caregiving and a full time job, taking a leave of absence from work or letting their own well-being take a back seat to care for someone else – it goes without saying how overwhelming the responsibilities of a caregiver can be. 👏👏👏 followmefollowersinnovationmed

56 Days ago
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Can sugar cause cancer? It seems that evidence pointing this way was discovered in a study funded by the sugar industry nearly 50 years ago, but the work was never published. followmefollowersinnovationcan oncancercancerandsugarfightcan

59 Days ago
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The first robotic pill is under development. Many drugs can only be injected. But the first robotic pill will take the drug to the intestinal wall. followmefollowersinnovation roboticpillmednextmedicinext

64 Days ago
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World’s first digital medicine is now approved. For the first time a Digital Medicine embedded with a ingestible sensor is available. This is the first time a medication has been submitted for approval combined with a sensor within the medication tablet to measure actual medication-taking patterns and physiologic response. It is hoped that digital medicines may improve patient medication adherence, and that the data they collect will allow the physician to make better-informed decisions to tailor treatment to the individual patient’s needs. The tablet contains an ingestible sensor that communicates with a wearable sensor patch and a medical software application for measuring adherence in the treatment of adults with schizophrenia, acute treatment of manic and mixed episodes associated with bipolar I disorder, and as adjunctive therapy for the treatment of major depressive disorder in adults. When the tablet with the embedded ingestible sensor is taken, the sensor sends a signal to the wearable Proteus patch after it reaches the stomach. The patch records and time-stamps the information from the ingestible sensor in addition to collecting other patient metrics, including rest, body angle and activity patterns. This information is recorded and relayed to patients and their doctors (with patient consent) on a mobile phone or other Bluetooth-enabled device 👏👍 followmefollowerslike4likelike elike4followlikeforlikeinnovat

68 Days ago
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Pneumonia is the leading infectious cause of death for children under the age of 5, and yet it is one of the only solvable problems in global health. Today is WorldPneumoniaDay and let’s generate actions to stop this infection by strengthening investments in child health. followmefollowersinnovationmed

69 Days ago
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A new promissing drug has shown long-lasting effect in patients with neovascular age-related macular degeneration (nAMD), a leading cause of blindness. In neovascular AMD, abnormal blood vessels leak fluid into the eye, ultimately causing damage and blindness 👏 followmefollowersinnovationbli

72 Days ago
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An early stage clinical trial reported results in a misunderstood autoimmune disease called Sjögren’s syndrome–a disease that has no approved therapies for its underlying causes. Sjögren’s syndrome affects an estimated 0.2-4% of the population worldwide. Diagnosis is challenging because the disease can affect not only the eyes and mouth, but also a dozen other organ systems. Patients experience a range of symptoms, so they typically visit a range of specialists. The Trial attempts to stop Sjögren’s where it starts by blocking this interaction. They also happened to have a compound with the potential to interrupt the interaction. patients suffering from Sjögren’s syndrome, who he says are often misunderstood. They have dry eyes, and doctors prescribe eye drops. But drops aren’t enough. In Sjögren’s, the immune system can go haywire, causing swollen joints, lung and kidney disease, lymphoma and crippling fatigue. Followmefollowersinnovaitionme

75 Days ago
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Spinal muscular atrophy is a progressive motor neuron disease with an onset during infancy that results in failure to meet motor milestones and in death or the need for mechanical ventilation by 2 years of age. Is there any option for the improvement of this hurrible disease? Followmefollowersspinalmuscula scularatrophyawarnessinnovatio

78 Days ago
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Be aware when buying medicines online (when allowed in your country)! There are many websites that operate legally and offer convenience, privacy, and safeguards for purchasing medicines. But there are also many "rogue websites" that offer to sell potentially dangerous drugs that have not been checked for safety or effectiveness. followmefollowerslike4likelike elike4followlikeforlikelike4li ke4likesbackinnovationonlineme

83 Days ago
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Today is World Psoriasis Day. Psoriasis is a common, chronic autoimmune disease that affects an estimated 125 million people worldwide. followmefollowersfollow4follow ollowpsoriasisworldpsoriasisda

85 Days ago
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Back in the 1950s, scientists created models of proteins using wires and blocks to visualize molecular machinery. The models helped them understand how proteins work and interact with drugs. Later, computer graphics replaced wire models, adding richness and precision but losing a dimension. Now scientists are working to bring that third dimension back, only instead of using wires and blocks, they are using virtual reality (VR), which immerses users in a digitally rendered alternate world. These molecular walks are useful during the early stages of drug design, when chemists and biologists need to exchange a lot of ideas about a protein’s interactions with a potential small molecule drug. Narrowing down the options is valuable because chemists have thousands of molecules to choose from when improving candidate drugs. The more information they have about how well a small molecule fits, or how it might fit better, the more likely they are to choose an option that is safer or more effective at fighting disease. Followmefollowersvrinnovationm

89 Days ago
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Breast cancer vaccine. Yes, why not? It may soon be available 👏 followmefollowersinnovationbre onbreastcancercancerfightcance

92 Days ago
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When we think of our immune system, we imagine legions of soldiers with different skills protecting us from harm. But in certain situations, some immune cells are more foe than friend. Myeloid-derived suppressor cells (MDSCs), which regulate immune responses and tissue repair in healthy individuals, is one example. They can also rapidly expand during cancer and play an important role in tumorigenesis. In cancer, MDSCs cause suppression of various immune cells in the tumor microenvironment, mainly T cells, but also natural killer cells, and B cells. They aggressively promote tumor angiogenesis, tumor cell invasion, and migration. What shall be done? followmefollowersinnovationsci onsciencecancerfightcancerfigh

95 Days ago
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Inhaled corticosteroids. We all know steroids as doping agents, performance enhancers and big muscles. In 1960 beclomethasone was introduced as the first inhaled corticosteroid which changed the life of million asthmatics. Asthma deaths were common and no physicians really believed on the importance of corticosteroids. Today, so many years after, the inhaled corticosteroids still are the Golden standard in asthma treatment 👏. followmefollowerslike4likelike elike4followlikeforlikelikefor keforfollowfollow4followlikefo ikeforfollowasthmaICSinnovatio

96 Days ago
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Is immuno-oncology the new path to win the war against cancer? The concept that the immune system plays a critical role in anti-tumor responses has been demonstrated and more recently immune checkpoint therapy has started a revolution in the field of oncology research. Several research studies are ongoing to identify appropriate biomarkers and more recently a multi biomarkers approach is seen as the only path to advance Immunotherapies research. followmefollowersfollow4follow ollowfollowforfollowlike4likel likelikeforlikelike4followlike wlikeforfollowinnovationcancer

99 Days ago
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Today, October 12, is recognized as World Arthritis Day. Arthritis is very common but is not well understood. Actually, “arthritis” is not a single disease; it is an informal way of referring to joint pain or joint disease. There are more than 100 different types of arthritis and related conditions. People of all ages, sexes and races can and do have arthritis, and it is the leading cause of disability. More than 50 million adults and 300,000 children have some type of arthritis. It is most common among women and occurs more frequently as people get older.

102 Days ago
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A drug offers at least 6 years of cancer protection, data show. The drug has come to dominate the HPV vaccine market, and a new, large-scale, phase 3 study that shows its protection against certain cancers lasts six years will only serve to strengthen its case. It protects against HPV types that cause about 90% of cervical cancer cases, 90% of genital warts cases and about 80% of high-grade cervical lesions worldwide. The shot can also protect against around 90% of HPV-related vulvar cancers, vaginal cancers and anal cancers. followmefollowersfollow4follow ollowlike4likelikeforfollowlik owlikeforfollowlikeforlikefoll efollowforfollowcancerhpvinnov

103 Days ago
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Bronchiectasis, permanent damage to the airways, is universal in primary ciliary dyskinesia (PCD). Cilia are also important in determining organ placement and 50% of all individuals with PCD will have unusual organ-placement. It is a genetic rare disease with no beneficial treatment yet. followmefollowerslikeforlikeli ikelike4likelikeforfollowinnov

106 Days ago